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Job Reseach Foundation supports a Research grant of Translational Immunology in Environmental Medicine with 200,000 $

Research: Projects and Publications


Support of research on a molecular level

In order to conduct research on the cause of S. aureus lung infections in patients with STAT3-Hyper-IgE syndrome (STAT3-HIES) – a rare, inborn immune defect –, Dr Vera Schwierzeck, MD, and Professor Ellen Renner, MD, have initiated a research project. The goal of this project is to study the reaction of epithelial cells of STAT3-HIES patients in response to infections with S. aureus by means of molecular methods. This research has now become feasible because of a funding support from the Job Research Foundation. The Job Research Foundation is a non-profit foundation based in the US and will fund the research project of Translational Immunology in Environmental Medicine with 200,000 dollar over a period of two years.

Lung infection in HIES patients caused by the bacterium S. aureus

STAT3-HIES is an inherited disease which entails a dysregulation of the immune system. The affected patients are susceptible for severe skin abscesses and lung inflammations mainly due to an immune deficiency against the bacterium Staphylococcus aureus.

Infections with S. aureus are a problem for the public health sector because of the rise in antibiotica resistance and might become life-threatening for a broad population. Despite biggest global efforts, the immune defense against S. aureus has not been completely understood. Researchers at the Chair and Institute of Environmental Medicine are therefore studying this bacterium in various interdisciplinary project (see also: Stentzel et al., JID 2017, or Altunbulakli & Reiger, JACI 2018).

This project titled “Fighting Staphylococcus aureus infections at the mucosal surface in Job syndrome” of the research team Translational Immunology in Environmental Medicine will extend the research on S. aureus at the Institute of Environmental Medicine. With this project, the researchers of Professor Renner´s team do not only want to make a significant contribution to the improvement of therapy for STAT3-HIES, but expect that their research will provide basic knowledge against S. aureus infections improving patient care.


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S.aureus (Foto: UNIKA-T)The photo depicts isolates of S. aureus (Latin „aureus“ means „golden“). Note the two different gold variants of the bacterial colonies left and right. The samples stem from two study participants of the UNIKA-T Study Center of Environmental Medicine. (Photo: V. Schwierzeck/UNIKA-T)